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REGULATORY RNA

CIRCling the wagons to protect intestinal stem cells

Nature Immunologyvolume 20pages114116 (2019) | Download Citation

Innate lymphoid cell–derived cytokine IL-13 promotes the maintenance of intestinal stem cells through stabilization of β-catenin. The circular RNA circPan3 regulates mRNA encoding the cytokine receptor subunit IL-13Rα and downstream IL-13 signaling to stabilize the β-catenin pathway in intestinal stem cells.

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Author information

Affiliations

  1. Department of Immunology, School of Medicine, University of Washington, Seattle, WA, USA

    • Frank Soveg
    • , Jakob von Moltke
    •  & Ram Savan

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Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Ram Savan.

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DOI

https://doi.org/10.1038/s41590-018-0302-0

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