INNATE IMMUNITY

STIM1 moonlights as an anchor for STING

Activation of STING requires its translocation from the endoplasmic reticulum (ER) through the Golgi to vesicles, but the mechanisms that control its localization have been unclear. The ER calcium sensor STIM1 acts as an ER-retention factor that anchors STING on the ER and limits STING signaling.

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Fig. 1: STIM1 is an ER-retention factor for STING.

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Correspondence to Nan Yan.

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Wu, J., Yan, N. STIM1 moonlights as an anchor for STING. Nat Immunol 20, 112–114 (2019). https://doi.org/10.1038/s41590-018-0300-2

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