News & Views | Published:

INNATE IMMUNE SENSORS

G3BP1 enhances cytoplasmic DNA pattern recognition

The stress-granule protein G3BP1 forms a high-molecular-weight protein complex with the sensor cGAS and enhances its detection of cytoplasmic DNA.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Kedersha, N. et al. J. Cell Biol. 169, 871–884 (2005).

  2. 2.

    Decker, C. J., Parker, R., Parker, R. & Parker, R. Cold Spring Harb. Perspect. Biol. 4, a012286 (2012).

  3. 3.

    Alam, U. & Kennedy, D. Biochim. Biophys. Acta Mol. Cell Res. https://doi.org/10.1016/j.bbamcr.2018.09.001 (2018).

  4. 4.

    Liu et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0262-4 (2018).

  5. 5.

    Chen, Q., Sun, L. & Chen, Z. J. Nat. Immunol. 17, 1142–1149 (2016).

  6. 6.

    Gao, P. et al. Cell 153, 1094–1107 (2013).

  7. 7.

    Dhanwani, R., Takahashi, M. & Sharma, S. Curr. Opin. Immunol. 50, 82–87 (2018).

  8. 8.

    Shim, J. H. et al. Cancer Prev. Res. (Phila.) 3, 670–679 (2010).

  9. 9.

    Reineke, L. C. & Lloyd, R. E. J. Virol. 89, 2575–2589 (2015).

  10. 10.

    Du, M. & Chen, Z. J. Science 361, 704–709 (2018).

  11. 11.

    Kuzuhara, T., Sei, Y., Yamaguchi, K., Suganuma, M. & Fujiki, H. J. Biol. Chem. 281, 17446–17456 (2006).

  12. 12.

    Crow, Y. J. et al. Nat. Genet. 38, 917–920 (2006).

  13. 13.

    Ohishi, T., Goto, S., Monira, P., Isemura, M. & Nakamura, Y. Antiinflamm. Antiallergy Agents Med. Chem. 15, 74–90 (2016).

Download references

Author information

Competing interests

The authors declare no competing interests.

Correspondence to Manuel Ascano.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark
Fig. 1: G3BP1 primes cGAS for efficient DNA binding and activation.