Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

INNATE IMMUNE SENSORS

G3BP1 enhances cytoplasmic DNA pattern recognition

The stress-granule protein G3BP1 forms a high-molecular-weight protein complex with the sensor cGAS and enhances its detection of cytoplasmic DNA.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Purchase on Springer Link

Instant access to full article PDF

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: G3BP1 primes cGAS for efficient DNA binding and activation.

References

  1. Kedersha, N. et al. J. Cell Biol. 169, 871–884 (2005).

    Article  CAS  Google Scholar 

  2. Decker, C. J., Parker, R., Parker, R. & Parker, R. Cold Spring Harb. Perspect. Biol. 4, a012286 (2012).

    Article  Google Scholar 

  3. Alam, U. & Kennedy, D. Biochim. Biophys. Acta Mol. Cell Res. https://doi.org/10.1016/j.bbamcr.2018.09.001 (2018).

  4. Liu et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0262-4 (2018).

  5. Chen, Q., Sun, L. & Chen, Z. J. Nat. Immunol. 17, 1142–1149 (2016).

    Article  CAS  Google Scholar 

  6. Gao, P. et al. Cell 153, 1094–1107 (2013).

    Article  CAS  Google Scholar 

  7. Dhanwani, R., Takahashi, M. & Sharma, S. Curr. Opin. Immunol. 50, 82–87 (2018).

    Article  CAS  Google Scholar 

  8. Shim, J. H. et al. Cancer Prev. Res. (Phila.) 3, 670–679 (2010).

    Article  CAS  Google Scholar 

  9. Reineke, L. C. & Lloyd, R. E. J. Virol. 89, 2575–2589 (2015).

    Article  Google Scholar 

  10. Du, M. & Chen, Z. J. Science 361, 704–709 (2018).

    Article  CAS  Google Scholar 

  11. Kuzuhara, T., Sei, Y., Yamaguchi, K., Suganuma, M. & Fujiki, H. J. Biol. Chem. 281, 17446–17456 (2006).

    Article  CAS  Google Scholar 

  12. Crow, Y. J. et al. Nat. Genet. 38, 917–920 (2006).

    Article  CAS  Google Scholar 

  13. Ohishi, T., Goto, S., Monira, P., Isemura, M. & Nakamura, Y. Antiinflamm. Antiallergy Agents Med. Chem. 15, 74–90 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Manuel Ascano.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wiser, C., Kim, B. & Ascano, M. G3BP1 enhances cytoplasmic DNA pattern recognition. Nat Immunol 20, 5–7 (2019). https://doi.org/10.1038/s41590-018-0279-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-018-0279-8

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing