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CD8 helps TCR catch slippery self pMHC

A new model proposes that an applied force allows the co-receptor CD8 and the kinase Lck to selectively stabilize TCR interactions with negatively selecting ligands, but not those with positively selecting ligands, during the negative selection of self-reactive thymocytes.

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Fig. 1: Molecular forces separate the lifetimes of positively selecting ligands from those of negatively selecting ligands.


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Correspondence to Michael L. Dustin.

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Dushek, O., Dustin, M.L. CD8 helps TCR catch slippery self pMHC. Nat Immunol 19, 1280–1281 (2018).

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