CD8 helps TCR catch slippery self pMHC

Article metrics

A new model proposes that an applied force allows the co-receptor CD8 and the kinase Lck to selectively stabilize TCR interactions with negatively selecting ligands, but not those with positively selecting ligands, during the negative selection of self-reactive thymocytes.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Molecular forces separate the lifetimes of positively selecting ligands from those of negatively selecting ligands.


  1. 1.

    Stepanek, O. et al. Cell 159, 333–345 (2014).

  2. 2.

    Hong, J. et al. Nat. Immunol. (2018).

  3. 3.

    Dembo, M., Torney, D. C., Saxman, K. & Hammer, D. Proc. Royal Soc. London. Series B 234, 55–83 (1988).

  4. 4.

    Marshall, B. T. et al. Nature 423, 190–193 (2003).

  5. 5.

    Kim, J., Zhang, C. Z., Zhang, X. & Springer, T. A. Nature 466, 992–995 (2010).

  6. 6.

    Das, D. K. et al. Proc. Natl Acad. Sci. USA 112, 1517–1522 (2015).

  7. 7.

    Dushek, O. & van der Merwe, P. A. Trends Immunol. 35, 153–158 (2014).

  8. 8.

    Chen, S. & Springer, T. A. J. Cell Biol. 144, 185–200 (1999).

  9. 9.

    Hailman, E., Burack, W. R., Shaw, A. S., Dustin, M. L. & Allen, P. M. Immunity 16, 839–848 (2002).

  10. 10.

    Sibener, L. V. et al. Cell 174, 672–687 (2018).

Download references

Author information

Correspondence to Michael L. Dustin.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Dushek, O., Dustin, M.L. CD8 helps TCR catch slippery self pMHC. Nat Immunol 19, 1280–1281 (2018) doi:10.1038/s41590-018-0261-5

Download citation