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THYMOCYTE SELECTION

CD8 helps TCR catch slippery self pMHC

Nature Immunologyvolume 19pages12801281 (2018) | Download Citation

A new model proposes that an applied force allows the co-receptor CD8 and the kinase Lck to selectively stabilize TCR interactions with negatively selecting ligands, but not those with positively selecting ligands, during the negative selection of self-reactive thymocytes.

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Author information

Affiliations

  1. Sir William Dunn School of Pathology, University of Oxford, Oxford, UK

    • Omer Dushek
  2. The Kennedy Institute of Rheumatology, Oxford, UK

    • Michael L. Dustin

Authors

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Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Michael L. Dustin.

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DOI

https://doi.org/10.1038/s41590-018-0261-5

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