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TUMOR IMMUNOEVASION

Tumors sweeten macrophages with acids

Acidic microenvironments induced by highly glycolytic tumor cells promote the noninflammatory polarization of tumor-associated macrophages, which leads to immunoevasion.

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Fig. 1: Instruction of macrophages by the acidification of tumor microenvironments.

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Correspondence to Hozumi Motohashi.

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Sekine, H., Yamamoto, M. & Motohashi, H. Tumors sweeten macrophages with acids. Nat Immunol 19, 1281–1283 (2018). https://doi.org/10.1038/s41590-018-0258-0

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