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TUMOR IMMUNOEVASION

Tumors sweeten macrophages with acids

Nature Immunologyvolume 19pages12811283 (2018) | Download Citation

Acidic microenvironments induced by highly glycolytic tumor cells promote the noninflammatory polarization of tumor-associated macrophages, which leads to immunoevasion.

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Author information

Affiliations

  1. Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan

    • Hiroki Sekine
    •  & Hozumi Motohashi
  2. Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan

    • Masayuki Yamamoto

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Competing interests

The authors declare no competing interests

Corresponding author

Correspondence to Hozumi Motohashi.

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DOI

https://doi.org/10.1038/s41590-018-0258-0

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