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γC CYTOKINE SIGNALING

Remote control of γc expression by arginine methylation

Arginine methylation is a post-translational modification that controls the abundance of γc cytokine receptor on mature T cells by a post-transcriptional mechanism.

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Fig. 1: The ‘butterfly effect’ of arginine methylation on the expression of and signaling via γc cytokine receptors.

References

  1. Waickman, A. T., Park, J. Y. & Park, J. H. Cell. Mol. Life Sci. 73, 253–269 (2016).

    Article  CAS  Google Scholar 

  2. Inoue, M. et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0222-z (2018).

    Article  Google Scholar 

  3. Blanc, R. S. & Richard, S. Mol. Cell 65, 8–24 (2017).

    Article  CAS  Google Scholar 

  4. Geoghegan, V., Guo, A., Trudgian, D., Thomas, B. & Acuto, O. Nat. Commun. 6, 6758 (2015).

    Article  CAS  Google Scholar 

  5. Liu, F. et al. J. Clin. Invest. 125, 3532–3544 (2015).

    Article  Google Scholar 

  6. Tee, W. W. et al. Genes Dev. 24, 2772–2777 (2010).

    Article  CAS  Google Scholar 

  7. Bendelac, A., Savage, P. B. & Teyton, L. Annu. Rev. Immunol. 25, 297–336 (2007).

    Article  CAS  Google Scholar 

  8. Bezzi, M. et al. Genes Dev. 27, 1903–1916 (2013).

    Article  CAS  Google Scholar 

  9. Friesen, W. J., Massenet, S., Paushkin, S., Wyce, A. & Dreyfuss, G. Mol. Cell 7, 1111–1117 (2001).

    Article  CAS  Google Scholar 

  10. Hong, C. et al. Immunity 40, 910–923 (2014).

    Article  CAS  Google Scholar 

  11. Markiewicz, S. et al. J. Biol. Chem. 271, 14849–14855 (1996).

    Article  CAS  Google Scholar 

  12. McCaughtry, T. M. et al. J. Exp. Med. 209, 2263–2276 (2012).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Jung-Hyun Park.

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Park, JY., Park, JH. Remote control of γc expression by arginine methylation. Nat Immunol 19, 1152–1154 (2018). https://doi.org/10.1038/s41590-018-0240-x

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