Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

γC CYTOKINE SIGNALING

Remote control of γc expression by arginine methylation

Nature Immunology volume 19, pages 1152–1154 (2018)Cite this article

Subjects

Arginine methylation is a post-translational modification that controls the abundance of γc cytokine receptor on mature T cells by a post-transcriptional mechanism.

T cells depend on signaling via cytokine receptors for their development, differentiation and survival. Chief among these receptors is γc, which is a shared receptor subunit for the binding and signaling of a series of cytokines that include interleukins IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21 and that are collectively referred to as ‘γc family cytokines’1. In addition to its importance in ligand binding, the γc receptor is also important because it is associated with the non-receptor tyrosine kinase JAK3, a key enzyme in triggering the proximal signaling events after cytokine ligation1. Despite their importance in T cell biology, however, the regulatory mechanisms for the expression of γc and JAK3 have remained mostly unknown. In the current issue of Nature Immunology, Inoue et al. report the unexpected finding that the arginine methlyltransferase PRMT5 has a critical role in controlling the abundance of both γc and JAK3 proteins in mature T cells2.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it

$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: The ‘butterfly effect’ of arginine methylation on the expression of and signaling via γc cytokine receptors.

References

  1. Waickman, A. T., Park, J. Y. & Park, J. H. Cell. Mol. Life Sci. 73, 253–269 (2016).

    Article  CAS  Google Scholar 

  2. Inoue, M. et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0222-z (2018).

    Article  Google Scholar 

  3. Blanc, R. S. & Richard, S. Mol. Cell 65, 8–24 (2017).

    Article  CAS  Google Scholar 

  4. Geoghegan, V., Guo, A., Trudgian, D., Thomas, B. & Acuto, O. Nat. Commun. 6, 6758 (2015).

    Article  CAS  Google Scholar 

  5. Liu, F. et al. J. Clin. Invest. 125, 3532–3544 (2015).

    Article  Google Scholar 

  6. Tee, W. W. et al. Genes Dev. 24, 2772–2777 (2010).

    Article  CAS  Google Scholar 

  7. Bendelac, A., Savage, P. B. & Teyton, L. Annu. Rev. Immunol. 25, 297–336 (2007).

    Article  CAS  Google Scholar 

  8. Bezzi, M. et al. Genes Dev. 27, 1903–1916 (2013).

    Article  CAS  Google Scholar 

  9. Friesen, W. J., Massenet, S., Paushkin, S., Wyce, A. & Dreyfuss, G. Mol. Cell 7, 1111–1117 (2001).

    Article  CAS  Google Scholar 

  10. Hong, C. et al. Immunity 40, 910–923 (2014).

    Article  CAS  Google Scholar 

  11. Markiewicz, S. et al. J. Biol. Chem. 271, 14849–14855 (1996).

    Article  CAS  Google Scholar 

  12. McCaughtry, T. M. et al. J. Exp. Med. 209, 2263–2276 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Joo-Young Park & Jung-Hyun Park

  2. Department of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, Seoul, South Korea

    Joo-Young Park

Authors
  1. Joo-Young Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jung-Hyun Park
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jung-Hyun Park.

Ethics declarations

Competing interests

The authors declare no competing interests

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Park, JY., Park, JH. Remote control of γc expression by arginine methylation. Nat Immunol 19, 1152–1154 (2018). https://doi.org/10.1038/s41590-018-0240-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-018-0240-x

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing