Review Article | Published:

The immune response against flaviviruses

Nature Immunologyvolume 19pages11891198 (2018) | Download Citation


Arthropod-borne flaviviruses are important human pathogens that cause a diverse range of clinical conditions, including severe hemorrhagic syndromes, neurological complications and congenital malformations. Consequently, there is an urgent need to develop safe and effective vaccines, a process requiring better understanding of the immunological mechanisms involved during infection. Decades of research suggest a paradoxical role of the immune response against flaviviruses: although the immune response is crucial for the control, clearance and prevention of infection, poor clinical outcomes are commonly associated with virus-specific immunity and immunopathogenesis. This relationship is further complicated by the high homology among viruses and the implication of cross-reactive immune responses in protection and pathogenesis. This Review examines the dual role of the adaptive immune response against flaviviruses, particularly emphasizing the most recent findings regarding cross-reactive T cell and antibody responses, and the effects that these concepts have on vaccine-development endeavors.

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This work was supported by the Wellcome Trust, UK, and the Newton-Medical Research Council, UK. G.R.S. is supported as a Wellcome Trust Senior Investigator.

Author information


  1. Nuffield Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK

    • Jose Luis Slon Campos
    •  & Juthathip Mongkolsapaya
  2. Dengue Hemorrhagic Fever Research Unit, Office for Research and Development, Siriraj Hospital, Faculty of Medicine, Mahidol University, Bangkok, Thailand

    • Juthathip Mongkolsapaya
  3. Division of Medical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK

    • Gavin R. Screaton


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Correspondence to Gavin R. Screaton.

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