Receptor-interacting protein (RIP) kinases, in particular RIPK1, RIPK2 and RIPK3, have emerged as pleiotropic modulators of inflammatory responses that act either by directly regulating intracellular inflammatory signaling pathways or by causing apoptotic or necrotic cell death. In this Review, we discuss the signaling pathways and immunological functions of these RIP kinases in the inflammatory response to microbial infection and tissue injury, as well as their potential roles in the pathogenesis of inflammatory disease and aging.
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Supported by the National Basic Research (973) Program of China (2013CB910102), the National Natural Science Foundation of China (31471303 and 31671436), a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions and Fok Ying Tung Education Foundation for Young Teachers (151020) and the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2017NL31002,2017NL31004).
The authors declare no competing interests.
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He, S., Wang, X. RIP kinases as modulators of inflammation and immunity. Nat Immunol 19, 912–922 (2018). https://doi.org/10.1038/s41590-018-0188-x
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