News & Views | Published:

HUMORAL IMMUNITY

PI3Kδ: Too much of a good thing

PI3Kδ regulates adaptive immune thresholds and limits immunity to endogenous microbiota.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Preite, S. et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0182-3 (2018).

  2. 2.

    Michalovich, D. & Nejentsev, S. Front. Immunol. 9, 369 (2018).

  3. 3.

    Okkenhaug, K. Annu. Rev. Immunol. 31, 675–704 (2013).

  4. 4.

    Manning, B. D. & Toker, A. Cell 169, 381–405 (2017).

  5. 5.

    Victora, G. D. & Nussenzweig, M. C. Annu. Rev. Immunol. 30, 429–457 (2012).

  6. 6.

    De Silva, N. S. & Klein, U. Nat. Rev. Immunol. 15, 137–148 (2015).

  7. 7.

    Victora, G. D. et al. Cell 143, 592–605 (2010).

  8. 8.

    Liu, D. et al. Nature 517, 214–218 (2015).

  9. 9.

    Vinuesa, C. G., Linterman, M. A., Yu, D. & MacLennan, I. C. Annu. Rev. Immunol. 34, 335–368 (2016).

  10. 10.

    Coulter, T. I. et al. J. Allergy Clin. Immunol. 139, 597–606 (2017).

  11. 11.

    Burnett, D. L. et al. Science 360, 223–226 (2018).

  12. 12.

    Bunker, J. J. et al. Science 358, eaan6619 (2017).

  13. 13.

    Bunker, J. J. et al. Immunity 43, 541–553 (2015).

Download references

Author information

Competing interests

The authors declare no competing interests.

Correspondence to Marcus R. Clark.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark
Fig. 1: PI3Kδ regulates lymphocyte activation.