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HUMORAL IMMUNITY

PI3Kδ: Too much of a good thing

PI3Kδ regulates adaptive immune thresholds and limits immunity to endogenous microbiota.

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Fig. 1: PI3Kδ regulates lymphocyte activation.

References

  1. Preite, S. et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0182-3 (2018).

  2. Michalovich, D. & Nejentsev, S. Front. Immunol. 9, 369 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Okkenhaug, K. Annu. Rev. Immunol. 31, 675–704 (2013).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  4. Manning, B. D. & Toker, A. Cell 169, 381–405 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. Victora, G. D. & Nussenzweig, M. C. Annu. Rev. Immunol. 30, 429–457 (2012).

    Article  PubMed  CAS  Google Scholar 

  6. De Silva, N. S. & Klein, U. Nat. Rev. Immunol. 15, 137–148 (2015).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Victora, G. D. et al. Cell 143, 592–605 (2010).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Liu, D. et al. Nature 517, 214–218 (2015).

    Article  PubMed  CAS  Google Scholar 

  9. Vinuesa, C. G., Linterman, M. A., Yu, D. & MacLennan, I. C. Annu. Rev. Immunol. 34, 335–368 (2016).

    Article  PubMed  CAS  Google Scholar 

  10. Coulter, T. I. et al. J. Allergy Clin. Immunol. 139, 597–606 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  11. Burnett, D. L. et al. Science 360, 223–226 (2018).

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  12. Bunker, J. J. et al. Science 358, eaan6619 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  13. Bunker, J. J. et al. Immunity 43, 541–553 (2015).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

Download references

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Correspondence to Marcus R. Clark.

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Kennedy, D.E., Clark, M.R. PI3Kδ: Too much of a good thing. Nat Immunol 19, 910–911 (2018). https://doi.org/10.1038/s41590-018-0183-2

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