Meeting Report | Published:

Tuberculous meningitis: a roadmap for advancing basic and translational research

Nature Immunologyvolume 19pages521525 (2018) | Download Citation

Tuberculous meningitis is a serious, life-threatening disease affecting vulnerable populations, including HIV-infected individuals and young children. The US National Institutes of Health convened a workshop to identify knowledge gaps in the molecular and immunopathogenic mechanisms of tuberculous meningitis and to develop a roadmap for basic and translational research that could guide clinical studies.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Chiang, S. S. et al. Lancet Infect. Dis. 14, 947–957 (2014).

  2. 2.

    Prasad, K., Singh, M. B. & Ryan, H. Cochrane Database Syst. Rev (4), CD002244 (2016)..

  3. 3.

    Sánchez-Garibay, C., Hernández-Campos, M. E., Tena-Suck, M. L. & Salinas-Lara, C. Tuberculosis 110, 1–6 (2018).

  4. 4.

    Rich, A. R. & McCordock, H. A. Bull. Johns Hopkins Hosp. 52, 5–37 (1933).

  5. 5.

    Rohlwink, U. K. et al. Pediatr. Infect. Dis. J. 35, e301–e310 (2016).

  6. 6.

    Matyszak, M. K. & Perry, V. H. Neuroscience 64, 967–977 (1995).

  7. 7.

    Coureuil, M., Lécuyer, H., Bourdoulous, S. & Nassif, X. Nat. Rev. Microbiol. 15, 149–159 (2017).

  8. 8.

    Jain, S. K., Paul-Satyaseela, M., Lamichhane, G., Kim, K. S. & Bishai, W. R. J. Infect. Dis 193, 1287–1295 (2006).

  9. 9.

    Skerry, C. et al. PLoS One 8, e66310 (2013).

  10. 10.

    Thuong, N. T. T. et al. J. Infect. Dis. 215, 1020–1028 (2017).

  11. 11.

    van Laarhoven, A. et al. J. Infect. Dis. 215, 1029–1039 (2017).

  12. 12.

    van Laarhoven, A. et al. Lancet Infect. Dis. https://doi.org/10.1016/S1473-3099(18)30053-7 (2018).

  13. 13.

    Morris, D. et al. Front. Pharmacol. 5, 73 (2014).

  14. 14.

    Tsenova, L., Sokol, K., Freedman, V. H. & Kaplan, G. J. Infect. Dis. 177, 1563–1572 (1998).

  15. 15.

    Mai, N. T. et al. eLife 7, e33478 (2018).

  16. 16.

    Berger, N. A. et al. Br. J. Pharmacol. 175, 192–222 (2018).

  17. 17.

    DeMarco, V. P. et al. Antimicrob. Agents Chemother. 59, 5768–5774 (2015).

  18. 18.

    Ruslami, R. et al. Lancet Infect. Dis. 13, 27–35 (2013).

  19. 19.

    Heemskerk, A. D. et al. N. Engl. J. Med. 374, 124–134 (2016).

  20. 20.

    Sun, F. et al. Antimicrob. Agents Chemother. 58, 6297–6301 (2014).

  21. 21.

    Jullien, S., Ryan, H., Modi, M. & Bhatia, R. Cochrane Database Syst. Rev. 9, CD012091 (2016).

  22. 22.

    Tucker, E. W. et al. Dis. Model. Mech. 9, 1497–1506 (2016).

  23. 23.

    Tobin, D. M. et al. Cell 140, 717–730 (2010).

  24. 24.

    Weinstein, E. A. et al. Sci. Transl. Med. 6, 259ra146 (2014).

  25. 25.

    Bahr, N. C. et al. Lancet Infect. Dis. 18, 68–75 (2018).

Download references

Author information

Affiliations

  1. Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    • Sanjay K. Jain
    • , Elizabeth W. Tucker
    •  & Alvaro A. Ordonez
  2. Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    • Sanjay K. Jain
    • , Elizabeth W. Tucker
    •  & Alvaro A. Ordonez
  3. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    • Sanjay K. Jain
    •  & Alvaro A. Ordonez
  4. Departments of Molecular Genetics and Microbiology and of Immunology, Duke University School of Medicine, Durham, NC, USA

    • David M. Tobin
  5. Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    • Elizabeth W. Tucker
  6. Department of Basic Medical Sciences, Western University of Health Sciences, Pomona, CA, USA

    • Vishwanath Venketaraman
  7. Columbus Technologies, Inc., Contractor to the National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, MD, USA

    • Lakshmi Jayashankar
  8. Global Neurology Program, Division of Neuro-Immunology, Center for Virology and Vaccine Research, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    • Omar K. Siddiqi
  9. Department of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia

    • Omar K. Siddiqi
  10. Center for Infectious Disease Imaging, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA

    • Dima A. Hammoud
  11. Sabin Research Institute, Children’s Hospital Los Angeles, Los Angeles, CA, USA

    • Nemani V. Prasadarao
  12. Department of Pathology and Laboratory Medicine, University of Wisconsin–Madison School of Medicine and Public Health, Madison, WI, USA

    • Matyas Sandor
    •  & Zsuzsanna Fabry
  13. Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA

    • Richard Hafner

Authors

  1. Search for Sanjay K. Jain in:

  2. Search for David M. Tobin in:

  3. Search for Elizabeth W. Tucker in:

  4. Search for Vishwanath Venketaraman in:

  5. Search for Alvaro A. Ordonez in:

  6. Search for Lakshmi Jayashankar in:

  7. Search for Omar K. Siddiqi in:

  8. Search for Dima A. Hammoud in:

  9. Search for Nemani V. Prasadarao in:

  10. Search for Matyas Sandor in:

  11. Search for Richard Hafner in:

  12. Search for Zsuzsanna Fabry in:

Consortia

  1. on behalf of the NIH Tuberculous Meningitis Writing Group

    Competing interests

    The authors declare no competing interests.

    Corresponding authors

    Correspondence to Sanjay K. Jain or Zsuzsanna Fabry.

    About this article

    Publication history

    Published

    DOI

    https://doi.org/10.1038/s41590-018-0119-x

    Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing