Naive T cells migrate rapidly through the lymph node. A high-resolution look at the chemokine receptor CCR7 and integrin LFA-1 reveals that T cells remain highly responsive to their microenvironment via instantaneous tuning of chemokine-regulated actin flow and integrin-regulated adhesion.
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Oakes, P.W., Fowell, D.J. CCR7 fuels and LFA-1 grips. Nat Immunol 19, 516–518 (2018). https://doi.org/10.1038/s41590-018-0118-y