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HUMAN ANTIBODIES

High-affinity IgA against microbial glycans

Nature Immunologyvolume 19pages514515 (2018) | Download Citation

Human affinity-matured antibodies to Klebsiella pneumoniae lipopolysaccharide O-antigen have different patterns of glycan fine specificity without being polyreactive. These antibodies might constitute an important mechanism for homeostatic control of the intestinal microbiome.

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Author information

Affiliations

  1. Department of Chemical Engineering at The University of Texas at Austin, Austin, Texas, USA

    • Jiwon Lee
    •  & George Georgiou

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to George Georgiou.

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DOI

https://doi.org/10.1038/s41590-018-0116-0

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