Human affinity-matured antibodies to Klebsiella pneumoniae lipopolysaccharide O-antigen have different patterns of glycan fine specificity without being polyreactive. These antibodies might constitute an important mechanism for homeostatic control of the intestinal microbiome.
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Secretory IgA N-glycans contribute to the protection against E. coli O55 infection of germ-free piglets
Mucosal Immunology Open Access 24 September 2020
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Lee, J., Georgiou, G. High-affinity IgA against microbial glycans. Nat Immunol 19, 514–515 (2018). https://doi.org/10.1038/s41590-018-0116-0
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DOI: https://doi.org/10.1038/s41590-018-0116-0
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Secretory IgA N-glycans contribute to the protection against E. coli O55 infection of germ-free piglets
Mucosal Immunology (2021)