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γδ17 T CELLS

Got my γδ17 T cells to keep me warm

γδ T cells accumulate with age in adipose tissue and produce the cytokine IL-17, which controls the homeostasis of regulatory T cells and adaptive thermogenesis. Thus, maintenance of core body temperature unexpectedly relies on these adipose tissue–resident γδ17 T cells.

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Author information

Affiliations

  1. Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal

    • Pedro H. Papotto
    •  & Bruno Silva-Santos

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Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Bruno Silva-Santos.