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NK CELLS

Adaptive responses of innate lymphocytes

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The activating natural killer cell receptor NKG2C can specifically recognize peptides derived from the cytomegalovirus protein UL40 in the context of HLA-E. This drives the expansion of a population of adaptive NKG2C+ natural killer cells.

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References

  1. 1.

    Watzl, C. Adv. Immunol. 124, 137–170 (2014).

  2. 2.

    Hammer, Q. et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0082-6 (2018).

  3. 3.

    Halenius, A., Gerke, C. & Hengel, H. Cell. Mol. Immunol. 12, 139–153 (2015).

  4. 4.

    Cerwenka, A. & Lanier, L. L. Nat. Rev. Immunol. 16, 112–123 (2016).

  5. 5.

    Smith, H. R. et al. Proc. Natl Acad. Sci. USA 99, 8826–8831 (2002)..

  6. 6.

    Arase, H., Mocarski, E. S., Campbell, A. E., Hill, A. B. & Lanier, L. L. Science 296, 1323–1326 (2002).

  7. 7.

    Guma, M. et al. Blood 104, 3664–3671 (2004).

  8. 8.

    Schlums, H. et al. Immunity 42, 443–456 (2015).

  9. 9.

    Lee, J. et al. Immunity 42, 431–442 (2015).

  10. 10.

    Bjorkstrom, N. K. et al. J. Exp. Med. 208, 13–21 (2011).

  11. 11.

    Della Chiesa, M. et al. J. Immunol. 192, 1471–1479 (2014).

  12. 12.

    Koch, J., Steinle, A., Watzl, C. & Mandelboim, O. Trends Immunol. 34, 182–191 (2013).

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Author information

Affiliations

  1. Leibniz Research Centre for Working Environment and Human Factors (IfADo), TU-Dortmund, Dortmund, Germany

    • Carsten Watzl

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Competing interests

The author declares no competing interests.

Corresponding author

Correspondence to Carsten Watzl.