News & Views | Published:

ALLERGIES

IL-33 meets allergens at the gate

Nature Immunologyvolume 19pages318320 (2018) | Download Citation

Subjects

IL-33 is a mediator of allergic inflammation and is localized in mucosal tissues to respond rapidly to environmental insults. These include allergens themselves, which can directly activate IL-33 through their intrinsic proteolytic activity.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Lefrançais, E. et al. Proc. Natl Acad. Sci. USA 109, 1673–1678 (2012).

  2. 2.

    Lefrançais, E. et al. Proc. Natl Acad. Sci. USA 111, 15502–15507 (2014).

  3. 3.

    Cayrol, C. et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0067-5 (2018).

  4. 4.

    Scott, I.C. et al. Sci. Rep. 8, 3363 (2018).

  5. 5.

    Lüthi, A. U. et al. Immunity 31, 84–98 (2009).

  6. 6.

    Snelgrove, R. J. et al. J. Allergy Clin. Immunol. 134, 583–592 (2014).

  7. 7.

    Hong, J. et al. J. Biol. Chem. 286, 20078–20086 (2011).

  8. 8.

    Sokol, C. L., Barton, G. M., Farr, A. G. & Medzhitov, R. Nat. Immunol. 9, 310–318 (2008).

  9. 9.

    de Kleer, I. M. et al. Immunity 45, 1285–1298 (2016).

  10. 10.

    Palm, N. W. et al. Immunity 39, 976–985 (2013).

Download references

Author information

Affiliations

  1. Insight BioConsulting, Bainbridge Island, WA, USA

    • Dirk E. Smith

Authors

  1. Search for Dirk E. Smith in:

Competing interests

The author declares no competing interests.

Corresponding author

Correspondence to Dirk E. Smith.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/s41590-018-0069-3

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing