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ALLERGIES

IL-33 meets allergens at the gate

IL-33 is a mediator of allergic inflammation and is localized in mucosal tissues to respond rapidly to environmental insults. These include allergens themselves, which can directly activate IL-33 through their intrinsic proteolytic activity.

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Fig. 1: Release of IL-33 in the context of allergen exposure.

Katie Vicari/Nature Publishing Group

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Correspondence to Dirk E. Smith.

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Smith, D.E. IL-33 meets allergens at the gate. Nat Immunol 19, 318–320 (2018). https://doi.org/10.1038/s41590-018-0069-3

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