IL-33 is a mediator of allergic inflammation and is localized in mucosal tissues to respond rapidly to environmental insults. These include allergens themselves, which can directly activate IL-33 through their intrinsic proteolytic activity.
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The author declares no competing interests.
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Smith, D.E. IL-33 meets allergens at the gate. Nat Immunol 19, 318–320 (2018). https://doi.org/10.1038/s41590-018-0069-3
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