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Capturing resting T cells: the perils of PLL

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Fig. 1: PLL induces strong T cell signaling and profoundly alters TCR diffusional activity and organization.

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Acknowledgements

Supported by a Royal Society University Research Fellowship (UF120277 to S.F.L.) and Research Professorship (RP150066 to D.K.); the EPSRC (EP/L027631/1 to A.P.,); the Wellcome Trust (098274/Z/12/Z to S.J.D., and WT101609MA to R.A.F.); PA Cephalosporin Fund (C.E.); the Wolfson Imaging Centre Oxford (funded by the Wolfson Foundation and Wellcome Trust; 104924/14/Z/14); the Micron Advanced BioImaging Unit (Wellcome Trust Strategic Award 091911); the Medical Research Council (MC_UU_12010/Unit Programmes G0902418 and MC_UU_12025); an MRC/BBSRC/EPSRC award (MR/K01577X/1); and a Marie Skłodowska-Curie Intra-European grant (707348 to I.U.).

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A.M.S., A.P., M.F., R.A.F., J.B.S., M.J.W, F.S., I.U., J.M., C.A., K.A.G., M.A. and D.D. performed experiments; A.M.S., A.P., M.F., R.A.F., R.J.C, M.L.D., D.K., S.J.D., C.E. and S.F.L. drafted and/or edited the manuscript; D.K., S.J.D., C.E. and S.F.L. conceived of the study; and M.L.D., S.J.D., C.E. and S.F.L. supervised the experiments.

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Correspondence to Christian Eggeling or Steven F. Lee.

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The authors declare no competing financial interests.

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Santos, A.M., Ponjavic, A., Fritzsche, M. et al. Capturing resting T cells: the perils of PLL. Nat Immunol 19, 203–205 (2018). https://doi.org/10.1038/s41590-018-0048-8

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