Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Capturing resting T cells: the perils of PLL

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Fig. 1: PLL induces strong T cell signaling and profoundly alters TCR diffusional activity and organization.


  1. Lillemeier, B. F. et al. Nat. Immunol. 11, 90–96 (2010).

    Article  CAS  PubMed  Google Scholar 

  2. Sherman, E. et al. Immunity 35, 705–720 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Rossy, J., Owen, D. M., Williamson, D. J., Yang, Z. & Gaus, K. Nat. Immunol. 14, 82–89 (2013).

    Article  CAS  PubMed  Google Scholar 

  4. Maity, P. C. et al. Sci. Signal. 8, ra93 (2015).

    Article  PubMed  Google Scholar 

  5. Pageon, S. V. et al. Sci. Signal. 6, ra62 (2013).

    Article  PubMed  Google Scholar 

  6. James, J. R. et al. Proc. Natl. Acad. Sci. USA 104, 17662–17667 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Chang, V. T. et al. Nat. Immunol. 17, 574–582 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Kaizuka, Y., Douglass, A. D., Vardhana, S., Dustin, M. L. & Vale, R. D. J. Cell Biol. 185, 521–534 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Evans, R., Lellouch, A. C., Svensson, L., McDowall, A. & Hogg, N. Blood 117, 3331–3342 (2011).

    Article  CAS  PubMed  Google Scholar 

  10. Sood, N., Bhardwaj, A., Mehta, S. & Mehta, A. Drug Deliv. 23, 758–780 (2016).

    PubMed  Google Scholar 

Download references


Supported by a Royal Society University Research Fellowship (UF120277 to S.F.L.) and Research Professorship (RP150066 to D.K.); the EPSRC (EP/L027631/1 to A.P.,); the Wellcome Trust (098274/Z/12/Z to S.J.D., and WT101609MA to R.A.F.); PA Cephalosporin Fund (C.E.); the Wolfson Imaging Centre Oxford (funded by the Wolfson Foundation and Wellcome Trust; 104924/14/Z/14); the Micron Advanced BioImaging Unit (Wellcome Trust Strategic Award 091911); the Medical Research Council (MC_UU_12010/Unit Programmes G0902418 and MC_UU_12025); an MRC/BBSRC/EPSRC award (MR/K01577X/1); and a Marie Skłodowska-Curie Intra-European grant (707348 to I.U.).

Author information

Authors and Affiliations



A.M.S., A.P., M.F., R.A.F., J.B.S., M.J.W, F.S., I.U., J.M., C.A., K.A.G., M.A. and D.D. performed experiments; A.M.S., A.P., M.F., R.A.F., R.J.C, M.L.D., D.K., S.J.D., C.E. and S.F.L. drafted and/or edited the manuscript; D.K., S.J.D., C.E. and S.F.L. conceived of the study; and M.L.D., S.J.D., C.E. and S.F.L. supervised the experiments.

Corresponding authors

Correspondence to Christian Eggeling or Steven F. Lee.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Santos, A.M., Ponjavic, A., Fritzsche, M. et al. Capturing resting T cells: the perils of PLL. Nat Immunol 19, 203–205 (2018).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing