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BACTERIAL SECOND MESSENGER SENSING

ERAdP standing in the shadow of STING innate immune signaling

ERAdP, an endoplasmic reticulum (ER)-resident protein with similar mechanistic features as the innate immune adaptor STING, controls inflammatory cytokine release, but not that of type I interferon, in response to bacterial cyclic di-AMP.

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Fig. 1: ERAdP guides the inflammatory response of bacterial c-di-AMP through NF-κB, independent of the STING signalsome.

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Correspondence to Martin Roelsgaard Jakobsen.

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Jakobsen, M.R. ERAdP standing in the shadow of STING innate immune signaling. Nat Immunol 19, 105–107 (2018). https://doi.org/10.1038/s41590-017-0026-6

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