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Mitophagy in HSCs

Hyperactivated mitophagy in hematopoietic stem cells

Nature Immunology volume 19, pages 2–3 (2018)Cite this article

Damaged mitochondria are targeted for mitophagy by the Pink–Parkin ubiquitin pathway. The mitochondrial ATPase Atad3a prevents aberrant activation of Pink and protects hematopoietic stem cells.

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Fig. 1: Deletion of Atad3a induces hyperactivated mitophagy through Parkin–Pink1 and impairs the homeostasis of HSCs and progenitor cells.

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Authors and Affiliations

  1. Cancer Science Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Chong Yang & Toshio Suda

  2. Kumamoto University, International Research Center for Medical Sciences, Kumamoto, Japan

    Toshio Suda

Authors
  1. Chong Yang
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  2. Toshio Suda
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Correspondence to Toshio Suda.

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Yang, C., Suda, T. Hyperactivated mitophagy in hematopoietic stem cells. Nat Immunol 19, 2–3 (2018). https://doi.org/10.1038/s41590-017-0008-8

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