Dynamic metabolic signatures underpin B cell function throughout development, maturation and differentiation. Germinal center B cells rely on MTHFD2-driven one-carbon metabolism that is dependent on antioxidant availability, purine synthesis and mTORC1 signaling.
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References
Vivas-García, Y. & Efeyan, A. Front. Mol. Biosci. 9, 991188 (2022).
Wu, J. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-024-01690-6 (2024).
Pardo-Lorente, N. & Sdelci, S. npj Metab. Health Dis. 2, 3 (2024).
Ducker, G. S. et al. Cell Metab. 23, 1140–1153 (2016).
Sugiura, A. et al. Immunity 55, 65–81.e9 (2022).
Wheeler, M. L. & DeFranco, A. L. J. Immunol. 189, 4405–4416 (2012).
Wang, L. V. et al. Cell Metab. 30, 539–555.e11 (2019).
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Steiner, R., Jellusova, J. One-carbon footprint in B cells. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01703-4
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DOI: https://doi.org/10.1038/s41589-024-01703-4