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Immunometabolism

One-carbon footprint in B cells

Dynamic metabolic signatures underpin B cell function throughout development, maturation and differentiation. Germinal center B cells rely on MTHFD2-driven one-carbon metabolism that is dependent on antioxidant availability, purine synthesis and mTORC1 signaling.

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Fig. 1: MTHFD2 governs GC B cell responses by facilitating purine and GSH production.

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Correspondence to Julia Jellusova.

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Steiner, R., Jellusova, J. One-carbon footprint in B cells. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01703-4

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