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Natural product biosynthesis

Solving the mystery of enediyne biosynthesis

Nature Chemical Biology volume 20, pages 1100–1102 (2024)Cite this article

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The biosynthetic intermediate of the common core of enediyne natural products has been enigmatic for decades. Now, researchers report the identification of a diiodotetrayne compound as the universal enediyne biosynthetic intermediate.

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Fig. 1: The chemistry and biology of enediynes.

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Authors and Affiliations

  1. Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA

    Max B. Sosa & Michelle C. Y. Chang

  2. Department of Chemical & Biomolecular Engineering, University of California, Berkeley, Berkeley, CA, USA

    Michelle C. Y. Chang

  3. Department of Molecular & Cell Biology, University of California, Berkeley, Berkeley, CA, USA

    Michelle C. Y. Chang

  4. Department of Chemistry, Princeton University, Princeton, NJ, USA

    Michelle C. Y. Chang

Authors
  1. Max B. Sosa
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  2. Michelle C. Y. Chang
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Correspondence to Michelle C. Y. Chang.

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The authors declare no competing interests.

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Sosa, M.B., Chang, M.C.Y. Solving the mystery of enediyne biosynthesis. Nat Chem Biol 20, 1100–1102 (2024). https://doi.org/10.1038/s41589-024-01686-2

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