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High-resolution structure of a novel fluorogenic RNA aptamer

Fluorogenic RNA aptamers have previously been developed to enhance RNA imaging. We determined the tertiary complex structures of a newly discovered Clivia aptamer, which exhibits a small size and a large Stokes shift. Structural insights into the fluorescence activation mechanism of Clivia build a strong foundation for its efficient use in RNA imaging.

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Fig. 1: Tertiary structure and the NBSI binding pocket of the Clivia aptamer.

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This is a summary of: Huang, K. et al. Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift. Nat. Chem. Biol. https://doi.org/10.1038/s41589-024-01633-1 (2024).

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High-resolution structure of a novel fluorogenic RNA aptamer. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01652-y

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