Two recent studies identify derivatives of (+)-JQ1, a non-degrading inhibitor of BET bromodomains, as molecular glues that recruit DCAF16 and DCAF11 via mechanisms involving stabilization of transient target–ligase interactions.
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F.M.F. is a scientific co-founder and equity holder in Proximity Therapeutics; was previously a scientific advisory board member of Triana Biomedicines; and is or was recently a consultant or received speaking honoraria from Eli Lilly, RA Capital, Tocris BioTechne and Plexium Inc. The Ferguson lab receives or has received research funding or resources in kind from Ono Pharmaceutical, Eli Lilly and Merck. F.M.F.’s interests have been reviewed and approved by the University of California San Diego in accordance with its conflict of interest policies.
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Wang, Y., Mouli, M.S.S.V., Ma, M. et al. Making transient complexes stick. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01649-7
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DOI: https://doi.org/10.1038/s41589-024-01649-7
