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Infectious disease

Channeling kynurenine

An in vivo chemical screen has uncovered a potential role for a tryptophan metabolite in promoting host survival during bacterial infections through modulation of ionotropic glutamate receptors. Host-directed therapies for bacterial infections offer a largely untapped approach to treatment.

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Fig. 1: A tryptophan metabolite, identified as a potent host-protective compound, mediates its effects via ionotropic glutamate receptor antagonism.

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Correspondence to David M. Tobin.

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Sweeney, M.I., Tobin, D.M. Channeling kynurenine. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01643-z

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