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A bright green tag for RNA imaging

To understand the complex dynamics and diverse functions of RNA, robust technologies for labeling and imaging RNA are highly desirable. A newly developed green fluorescent aptamer named Okra enables the imaging of mRNA dynamics in living cells.

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Fig. 1: Imaging mRNA trafficking to stress granules with Okra.

References

  1. Zuo, F. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-024-01629-x (2024).

    Article  PubMed  Google Scholar 

  2. Li, W., Maekiniemi, A., Sato, H., Osman, C. & Singer, R. H. Nat. Methods 19, 1558–1562 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Braselmann, E., Rathbun, C., Richards, E. M. & Palmer, A. E. Cell Chem. Biol. 27, 891–903 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Sunbul, M. et al. Nat. Biotechnol. 39, 686–690 (2021).

    Article  CAS  PubMed  Google Scholar 

  5. Bühler, B. et al. Nat. Chem. Biol. 19, 478–487 (2023).

    Article  PubMed  Google Scholar 

  6. Wirth, R., Gao, P., Nienhaus, G. U., Sunbul, M. & Jäschke, A. J. Am. Chem. Soc. 141, 7562–7571 (2019).

    Article  CAS  PubMed  Google Scholar 

  7. Braselmann, E. et al. Nat. Chem. Biol. 14, 964–971 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Paige, J. S. et al. Science 333, 642–646 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Li, X., Kim, H., Litke, J. L., Wu, J. & Jaffrey, S. R. Angew. Chem. Int. Ed. 59, 4511–4518 (2020).

    Article  CAS  Google Scholar 

  10. Chen, X. et al. Nat. Biotechnol. 37, 1287–1293 (2019).

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Murat Sunbul.

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Sathyan, D., Sunbul, M. A bright green tag for RNA imaging. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01637-x

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