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Post-translational modifications

Bump-hole ZDHHCs

The ZDHHC family of palmitoyl transferases lipidates numerous protein targets, but the paucity of selective inhibitors has hindered their target profiling. A generalized chemical genetic system can now map the protein targets of individual ZDHHC family members.

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Fig. 1: Bump-hole strategy on ZDHHC family proteins.

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Correspondence to Bryan C. Dickinson.

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Lan, T., Dickinson, B.C. Bump-hole ZDHHCs. Nat Chem Biol 20, 666–667 (2024). https://doi.org/10.1038/s41589-024-01634-0

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