Ferroptosis, a cell death mechanism induced by lipid peroxidation, is pivotal in tumor suppression. A recent study shows that tumor repopulating cells evade ferroptosis and develop resistance to therapy via subverting a lipid metabolism enzyme.
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References
Prakash, R. & Telleria, C. M. Oncoscience 10, 14–19 (2023).
Stockwell, B. R. Cell 185, 2401–2421 (2022).
Lei, G., Zhuang, L. & Gan, B. Nat. Rev. Cancer 22, 381–396 (2022).
Li, Z. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-024-01612-6 (2024).
Doll, S. et al. Nat. Chem. Biol. 13, 91–98 (2017).
Kagan, V. E. et al. Nat. Chem. Biol. 13, 81–90 (2017).
Yang, W. S. et al. Cell 156, 317–331 (2014).
Gao, M. et al. Mol. Cell 73, 354–363.e3 (2019).
Mao, C. et al. Nature 593, 586–590 (2021).
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B.G. is an inventor on patent applications involving targeting ferroptosis in cancer therapy, and reports personal fees from Guidepoint Global, Cambridge Solutions, and NGM Bio. Y.Y. has no declaration of interests.
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Yan, Y., Gan, B. Dodging death. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01607-3
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DOI: https://doi.org/10.1038/s41589-024-01607-3
