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Artificial mechanoreceptors

Forced rewiring of RTK signaling

Reprogramming intercellular mechanotransduction and signaling pathways is still challenging. A recent advance uses a plug-and-play DNA nanodevice to allow non-mechanosensitive receptor tyrosine kinase (RTK) to transmit force-induced cellular signals.

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Fig. 1: A plug-and-play DNA-based artificial mechanoreceptor.


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Correspondence to Mingxu You.

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Ali, A.A., Tabrizi, M.A. & You, M. Forced rewiring of RTK signaling. Nat Chem Biol (2024).

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