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Chemical probes

A key to unlock ubiquitin ligase function

Reliably identifying ubiquitin ligase interactors and substrates has been a persistent challenge in cellular biology. A breakthrough comes in the form of a potent, selective and cell-active chemical probe, shedding light on the intricate functions of a key regulatory enzyme.

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Fig. 1: Dissecting GID4 interactors through competitive proximity labeling with the chemical probe PFI-7.


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Correspondence to Gang Li.

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Xie, S., Li, G. A key to unlock ubiquitin ligase function. Nat Chem Biol (2024).

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