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Peptides

Ripping and stitching with copper

Nature Chemical Biology volume 20, pages 404–405 (2024)Cite this article

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BURP-domain proteins belong to an emerging class of autocatalytic copper-containing proteins that modify themselves after synthesis. Now, a report explains how their structure and metal coordination sphere control the installation of crosslinks within the core peptide, and shows how nature leverages mechanistic paradigms to create diversity.

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Fig. 1: Structure and reactivity of the BURP domain.

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  1. Department of Chemical Physiology and Biochemistry, Oregon Health and Sciences University, Portland, OR, USA

    Ninian J. Blackburn

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  1. Ninian J. Blackburn
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Correspondence to Ninian J. Blackburn.

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Blackburn, N.J. Ripping and stitching with copper. Nat Chem Biol 20, 404–405 (2024). https://doi.org/10.1038/s41589-024-01582-9

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