The susceptibility of nitric oxide (NO) to scavenging and oxidation limits its bioavailability and signaling role. New studies indicate that a NO–ferroheme adduct is resistant to such constraints and may serve as an alternative NO-derived signaling molecule in vasculature.
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Martin, E. NO signal. Nat Chem Biol 19, 1178–1179 (2023). https://doi.org/10.1038/s41589-023-01421-3