The role of lipid membrane domains in the activation of immune cells remains elusive. New microscopy data on B cell signaling support a mechanism in which lipid membrane domains consolidate upon B cell receptor clustering.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Gaud, G., Lesourne, R. & Love, P. E. Nat. Rev. Immunol. 18, 485–497 (2018).
Shelby, S. A., Castello-Serrano, I., Wisser, K. C., Levental, I. & Veatch, S. L. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01268-8 (2023).
Hyman, A. A., Weber, C. A. & Julicher, F. Annu. Rev. Cell Dev. Biol. 30, 39–58 (2014).
Sezgin, E., Levental, I., Mayor, S. & Eggeling, C. Nat. Rev. Mol. Cell Biol. 18, 361–374 (2017).
Sych, T., Levental, K. R. & Sezgin, E. Annu. Rev. Biophys. 51, 135–156 (2022).
Stone, M. B., Shelby, S. A., Nunez, M. F., Wisser, K. & Veatch, S. L. eLife 6, e19891 (2017).
Urbančič, I. et al. FEBS Lett. 595, 2127–2146 (2021).
Klymchenko, A. S. Acc. Chem. Res. 56, 1–12 (2023).
Bolla, J. R., Agasid, M. T., Mehmood, S. & Robinson, C. V. Annu. Rev. Biochem. 88, 85–111 (2019).
Brameshuber, M. et al. Nat. Immunol. 19, 487–496 (2018).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Urbančič, I., Eggeling, C. & Sezgin, E. Do lipids tune B cell signaling?. Nat Chem Biol 19, 669–670 (2023). https://doi.org/10.1038/s41589-023-01303-8
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41589-023-01303-8
