Engineering synthetic tools that facilitate decision-making in mammalian cells could enable myriad biomedical applications. Researchers have now developed a new system of inducer-controlled transcription factors to facilitate synthetic decision-making (LOGIC) in human cells based on modular protein-fusion cascades.
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Huang, B.D., De Pereda, A.S. & Wilson, C.J. Synthesizing cellular LOGIC. Nat Chem Biol 19, 671–672 (2023). https://doi.org/10.1038/s41589-023-01280-y
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DOI: https://doi.org/10.1038/s41589-023-01280-y