Ferroptosis can be induced by lipid peroxidation in various subcellular membranes, including the endoplasmic reticulum (ER), mitochondria and lysosomes. By studying the subcellular distribution of ferroptosis-modulating fatty acids, we observed that the ER is a key initial site of peroxidation, followed by the plasma membrane, whereas other organelles are not as critical for ferroptosis.
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References
Stockwell, B. R. Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications. Cell 185, 2401–2421 (2022). A review article that provides a comprehensive overview of ferroptosis.
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This is a summary of: von Krusenstiern, A. N. et al. Identification of essential sites of lipid peroxidation in ferroptosis. Nat. Chem. Bio. https://doi.org/10.1038/s41589-022-01249-3 (2023).
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Determining the role of peroxidation of subcellular lipid membranes in ferroptosis. Nat Chem Biol 19, 674–675 (2023). https://doi.org/10.1038/s41589-022-01250-w
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DOI: https://doi.org/10.1038/s41589-022-01250-w
