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Determining the role of peroxidation of subcellular lipid membranes in ferroptosis

Ferroptosis can be induced by lipid peroxidation in various subcellular membranes, including the endoplasmic reticulum (ER), mitochondria and lysosomes. By studying the subcellular distribution of ferroptosis-modulating fatty acids, we observed that the ER is a key initial site of peroxidation, followed by the plasma membrane, whereas other organelles are not as critical for ferroptosis.

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Fig. 1: Ferroptosis can be induced in different membranes, but the ER is a key initial site of peroxidation.


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This is a summary of: von Krusenstiern, A. N. et al. Identification of essential sites of lipid peroxidation in ferroptosis. Nat. Chem. Bio. (2023).

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Determining the role of peroxidation of subcellular lipid membranes in ferroptosis. Nat Chem Biol (2023).

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