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To TnpB or not TnpB? Cas12 is the answer

Nature Chemical Biology volume 19, pages 263–264 (2023)Cite this article

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An Author Correction to this article was published on 16 February 2023

The Original Article was published on 01 August 2022

arising from: Kim, D. Y. et al. ‘Hypercompact adenine base editors based on transposase B guided by engineered RNA’, Nat. Chem. Biol. 18, 1005–1013 (2022); https://doi.org/10.1038/s41589-022-01077-5

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Fig. 1: Candidatus woesearchaeota-derived ‘TnpB’ is a bona fide Cas12f protein.

Data availability

All nucleotide and protein sequences presented here come from publicly available Genbank accession nos. MK005734, CP050120, CP014749 and DUFM01000066.

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Author information

Authors and Affiliations

  1. Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA

    Peter H. Yoon & Jennifer A. Doudna

  2. Innovative Genomics Institute, University of California, Berkeley, CA, USA

    Peter H. Yoon, Benjamin A. Adler & Jennifer A. Doudna

  3. California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, CA, USA

    Benjamin A. Adler & Jennifer A. Doudna

  4. Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA

    Benjamin A. Adler & Jennifer A. Doudna

  5. Howard Hughes Medical Institute, University of California, Berkeley, CA, USA

    Jennifer A. Doudna

  6. Department of Chemistry, University of California, Berkeley, CA, USA

    Jennifer A. Doudna

  7. MBIB Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA

    Jennifer A. Doudna

Authors
  1. Peter H. Yoon
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  2. Benjamin A. Adler
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  3. Jennifer A. Doudna
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Contributions

P.Y., B.A.A. and J.A.D. conceived of the critique, performed the analyses and wrote the manuscript.

Corresponding author

Correspondence to Jennifer A. Doudna.

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Competing interests

J.A.D. is a cofounder of Caribou Biosciences, Editas Medicine, Scribe Therapeutics, Intellia Therapeutics and Mammoth Biosciences. J.A.D. is a scientific advisory board member of Vertex, Caribou Biosciences, Intellia Therapeutics, Scribe Therapeutics, Mammoth Biosciences, Algen Biotechnologies, Felix Biosciences, The Column Group, Sixth Street and Inari. J.A.D. is a Director at Johnson & Johnson, Altos and Tempus and has research projects sponsored by AppleTree Partners and Roche. All other authors declare no competing interests.

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Yoon, P.H., Adler, B.A. & Doudna, J.A. To TnpB or not TnpB? Cas12 is the answer. Nat Chem Biol 19, 263–264 (2023). https://doi.org/10.1038/s41589-022-01243-9

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  • DOI: https://doi.org/10.1038/s41589-022-01243-9

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