Substrate–inhibitor conjugation facilitates structural determination of the KDM2A/B-nucleosome complexes, which provides mechanistic insights into the nucleosomal H3K36 demethylation by KDM2A/B and reveals a paralog-specific nucleosome acidic patch recognition mechanism mediated by the N terminus of KDM2A but not KDM2B.
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The authors declare no competing interests.
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Ai, H., Liu, L. Paralog-specific recognition. Nat Chem Biol 19, 542–543 (2023). https://doi.org/10.1038/s41589-022-01241-x