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Topoisomerase II and etoposide — a tangled tale

Etoposide, a chemotherapeutic poison of type IIA eukaryotic topoisomerases (topo IIs), promotes topo II to compact DNA by trapping DNA loops, creates DNA double-strand breaks, causes topo II to resist relocation, and pauses the ability of topoisomerases to relax DNA supercoiling. Through these mechanisms, etoposide converts topo II into a roadblock to DNA processing.

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Fig. 1: Etoposide promotes topo II-generated DNA breaks and stabilizes topo II-captured DNA loops.


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This is a summary of: Le, T. T. et al. Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II. Nat. Chem. Biol. (2023).

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Topoisomerase II and etoposide — a tangled tale. Nat Chem Biol 19, 546–547 (2023).

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