Small-molecule-mediated targeted protein degradation (TPD) relies on the recruitment of a target protein of interest to an E3 ligase. A new study indicates how direct target recruitment to the 26S proteasome can bypass this requirement.
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G.E.W. is scientific founder and shareholder of Proxygen and Solgate. The Winter lab receives research funding from Pfizer.
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Tin, G., Winter, G.E. CIDE-stepping E3s. Nat Chem Biol 19, 3–4 (2023). https://doi.org/10.1038/s41589-022-01217-x