Clustering and multimerization of cell surface proteins (CSPs) are essential for triggering downstream intracellular signaling events. Membrane-anchored liquid–liquid phase-separation systems have now been developed to manipulate the spatiotemporal distribution and activation of CSPs.
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Wang, Z., Zhang, H. Gathering on the cell surface. Nat Chem Biol 18, 1294–1295 (2022). https://doi.org/10.1038/s41589-022-01195-0