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Phase separation

Gathering on the cell surface

Nature Chemical Biology volume 18, pages 1294–1295 (2022)Cite this article

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Clustering and multimerization of cell surface proteins (CSPs) are essential for triggering downstream intracellular signaling events. Membrane-anchored liquid–liquid phase-separation systems have now been developed to manipulate the spatiotemporal distribution and activation of CSPs.

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Fig. 1: Bioengineered membrane-anchor-dependent phase-separation approaches to manipulate the multimerization and distribution of CSPs.

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Authors and Affiliations

  1. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

    Zheng Wang & Hong Zhang

  2. College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China

    Hong Zhang

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  1. Zheng Wang
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  2. Hong Zhang
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Correspondence to Hong Zhang.

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The authors declare no competing interests.

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Wang, Z., Zhang, H. Gathering on the cell surface. Nat Chem Biol 18, 1294–1295 (2022). https://doi.org/10.1038/s41589-022-01195-0

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