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Metabolic engineering

A balancing act

Inspired by nature, a synthetic carbon fixation cycle builds complex molecules directly from CO2. Building metabolism from the ground up requires several innovative advancements — now, a strategy to balance carbon demands in a complex metabolic network is explored.

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Fig. 1: Synthetic metabolism can enable the conversion of carbon dioxide into complex chemicals.

References

  1. Diehl, C., Gerlinger, P. D., Paczia, N. & Erb, T. J. Nat. Chem. Biol. https://doi.org/10.1038/s41589-022-01179-0 (2022).

    Article  Google Scholar 

  2. Lee, S. Y. et al. Nat. Catal. 2, 18–33 (2019).

    Article  CAS  Google Scholar 

  3. Liew, F. E. et al. Nat. Biotechnol. 40, 335–344 (2022).

    Article  CAS  Google Scholar 

  4. Rasor, B. J. et al. Curr. Opin. Biotechnol. 69, 136–144 (2021).

    Article  CAS  Google Scholar 

  5. Schwander, T., von Borzyskowski, L. S., Burgener, S., Cortina, N. S. & Erb, T. J. Science 354, 900–904 (2016).

    Article  CAS  Google Scholar 

  6. Sundaram, S. et al. Angew. Chem. Intl Edn https://doi.org/10.1002/anie.202102333 (2021).

    Article  Google Scholar 

  7. Schultheisz, H. L., Szymczyna, B. R., Scott, L. G. & Williamson, J. R. ACS Chem. Biol. 3, 499–511 (2008).

    Article  CAS  Google Scholar 

  8. Zhang, J. et al. Nature 609, 341–347 (2022).

    Article  CAS  Google Scholar 

  9. Opgenorth, P. H., Korman, T. P., Iancu, L. & Bowie, J. U. Nat. Chem. Biol. 13, 938–942 (2017).

    Article  CAS  Google Scholar 

  10. Sun, J., Jeffryes, J. G., Henry, C. S., Bruner, S. D. & Hanson, A. D. Metab. Eng. 44, 150–159 (2017).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Michael C. Jewett.

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Landwehr, G.M., Jewett, M.C. A balancing act. Nat Chem Biol 19, 127–128 (2023). https://doi.org/10.1038/s41589-022-01183-4

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  • DOI: https://doi.org/10.1038/s41589-022-01183-4

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