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Caught in the act

YcaO enzymes are able to catalyze a diverse set of reactions and have found industrial applications. New biochemical data provide the first direct evidence for the unified reaction mechanism proposed a decade ago and will inform future enzyme engineering efforts.

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Fig. 1: Reactions and the proposed mechanism of YcaO enzymes.


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Correspondence to Jesko Koehnke.

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The author declares no competing interests.

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Koehnke, J. Caught in the act. Nat Chem Biol 19, 7–8 (2023).

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